Chapter 1: Conceptualization First some history: Kraepelin is the of import grade in this chapter. Differentiated manic-depressive disease from dementedness praecox (SCZ). unify melancholia (DEP) and circular psychoses (BPAD, SAFD) into one category. His fundamental insight was that return secernate is key. Bleueler woolly the distinction again, putting SCZ and BPAD on a spectrum. SCZ sx were key and affective sx were non-specific. He set the stage for the unipolar-bipolar distinction. unipolar vs. bipolar: G/J spend much time literary argument that unipolar-bipolar belief is less helpful than the idea of recurrence. Heterogeneity: Unipolar illness very heterogeneous group. So is bipolar. Early compartmentalization schemes (1) turn out different epidemiology between MD, Md, dM and dm groups. Rates: umteen studies show that unipolar:bipolar ~1:1. So what is the unipolar/bipolar distinction: Phenomenology of Depression| bipolar| Unipolar| inhe ring Course| | | Age of onset| Young| overaged| | press range| Wider range| # sequences| more(prenominal)| little| Length chance| piteouser| Longer| Cycle length| Longer| shorter| Precipitant of circumstance| more than important at onset| ?| Inter-episode mood lability| more| less(prenominal)| | | | Marital Status| Not a RF| RF| | | | Epedimiology| | | Life time risk| 1.

5%| 10-15%| Gender| M=F| F>M| SA| more| little| | | | heritable science| More hereditary| less(prenominal)| | | | Biological| | | smart aesthesia| Less| More| Sleep duration| Long| dead| Sea sonal| D-fall/winter M-spring/summer| D-spri! ng| | | | Pharm| | | Response to AD| Less| More| Speed of response to AD| More| Less| Tolerance to ADs| More freq| Less freq| Switch w/ ADs| More| Less| Prophylactic response to ADs| Less| More| somewhat notes on mania: 1) unipolar mania is probably wonderful (<10% of BPAD). 2) Primacy of mania (2): all depression follows excitation release (mania, hypomania,...If you want to get a full essay, order it on our website:
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